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Attractive scientist Dr. Clare Wyatt (Anna Lee) fondly declines the proposal of journalist Dick Haslewood (John Loder), who loves her, and she goes to work for the reclusive Dr. Laurience (Boris Karloff), whom the scientific world regards as a crackpot. At Laurience's remote estate, she's greeted at the door by bitter, wheelchair-bound Clayton (Donald Calthrop), one of the doctor's more hopeless cases. Dick hangs around the neighborhood, sending stories to his newspaper, which is owned by his tycoon father, Lord Haslewood (Frank Cellier). Laurience demonstrates the reality of his discredited theory to an astonished Claire. Using an array of electrical equipment, he switches the minds of a good-natured and a cranky chimpanzee, then suggests to Claire that this could be done with people, making immortality possible. Lord Haslewood turns up unexpectedly, and offers the skeptical scientist the full use of the prestigious Haslewood Institute in exchange for the right to run stories on Laurience's progress, and to own the resulting patents. But problems arise when Haslewood sets up a conference of prominent scientists to hear Laurience explain the intent of his research. They all scoff loudly, and walk out. Lord Haslewood is furious, feeling he's been humiliated; he tells the shocked Laurience that he, not the scientist, owns everything, and orders him out of the Institute. Laurience suffers a mental breakdown, and invites Haslewood to his lab, where he straps him into the chair of his apparatus, then switches the minds of Haslewood and the crippled Clayton. When Haslewood realizes he's now in Clayton's body, he bursts into laughter and drops dead, puzzling the other two. Clayton is delighted to be in a body that's not only capable of walking, but is that of a financially powerful man. When Laurience offers Claire "eternal youth, eternal loveliness," she is shocked, and he realizes she's in love with Dick, so he makes plans for Dick to come to the Institute.

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