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In Stephens Sanitarium, therapy has been replaced by torture and necrophilia. By allowing each patient to act out his psychosis, the director believes that he can cure insanity. The doctor becomes the victim of his own experiment when he is brutally murdered by an inmate. Charlotte, a young nurse practiced in experimental psychology, joins the shrinking staff, but nothing can prepare her for the gruesome scenes that await her at the asylum. Under the guidance of the new director, the stronger patients prey on the weak, as they plunge deeper into madness. Charlotte's attempt to help turns into a fight for survival as the most violent and demented inmate emerges to take control of the entire hospital.

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