What’s Up, Doc? joyously recaptures the bubbly style of 1930s screwball comedies — and firmly establishes Barbra Streisand and Ryan O’Neal as a romantic duo uniquely endearing in screen history. Included are a daffy luggage mix-up plot, dippy dialogue exchanges, a marvelous example of the art of hotel-room demolition and one of the funniest chase sequences ever, all over San Francisco. Dexterously written with a surefooted sense of the ridiculous by Buck Henry, David Newman and Robert Benton; directed by Peter Bogdanovich with giddy affection; and cast with awesomely hilarious players (including film-debuting Madeline Kahn).